GHRP-2

GHRP-2 increases natural growth hormone production, promoting muscle growth, fat loss, better recovery, and improved overall health and wellness.

What is GHRP-2?

GHRP-2 is a synthetically made growth hormone secretagogue, a peptide that stimulates the body to increase natural production of growth hormone. Growth hormone, or GH, is made in and released by the pituitary gland. GHRP-2 works to enhance this natural GH production in two different ways. First, the peptide amplifies the natural growth hormone releasing signal. This results in a greater secretion of GH. Second, it suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone (GHIH). Somatostatin causes the body to reduce its natural GH output. By limiting the action of somatostatin, GHRP-2 removes this barrier to higher GH production, resulting in increased natural growth hormone levels. GHRP-2 also activates ghrelin, a peptide hormone produced in the gastrointestinal system. Ghrelin has strong stimulatory effects on both natural growth hormone production and appetite. However, unlike GHRP-6, GHRP-2 has been structurally modified to limit the appetite increasing effects of ghrelin.

Because GHRP-2 stimulates the body to produce GH, there is no shutdown of natural growth hormone production as occurs with synthetic hGH administration. GHRP-2 causes GH secretion in a way that more closely resembles natural release patterns, causing growth hormone to be released in a “pulse” type manner, rather than being constantly elevated. This results in fewer side effects compared with synthetic hGH. Even so, it is possible to achieve substantial increases in growth hormone levels with GHRP-2, as it is one of the most powerful growth hormone secretagogue peptides.

Amino Acid Sequence: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2

Molecular Formula: C45H55N9O6 

Molar Mass: 817.9

Also Known As: Pralmorelin

Benefits

The benefits of GHRP-2 include increased muscle mass, decreased body fat, and enhanced flexibility and joint health. It also promotes better recovery from injuries and training sessions, deeper, more restful sleep, anti-aging benefits, and improved overall health and wellness. Higher growth hormone levels also lead to greater production of Insulin-like Growth Factor 1 (IGF-1) in the body. This further drives improvements in lean body composition, accelerating growth of muscle tissue and reducing body fat. Likewise, GHRP-2 promotes significant gains in strength and endurance, especially when used for a period of months. Athletic performance, physical capacity, and aging-related decline all have the ability to improve dramatically with the use of this peptide.

GHRP-2 is widely regarded as one of the most effective growth hormone releasing peptides for both athletic performance and anti-aging effects. It promotes substantial increases in the body’s output of growth hormone while minimizing the powerful hunger side effects associated with GHRP-6. This may often lead to significant improvements in lean body composition. In addition, its method of action prevents many of the negative side effects of synthetic hGH administration, including the shutdown of natural growth hormone production.

GHRP-2 Vs. GHRP-6

GHRP-2 and GHRP-6 both work to increase natural GH production through similar ways. Each peptide stimulates the pituitary gland to secrete greater amounts of GH while inhibiting the action of somatostatin, the growth hormone inhibiting hormone. Additionally, both peptides also stimulate the action of ghrelin, a natural hormone that increases pituitary output of GH and also increases appetite. The most noticeable difference between GHRP-2 and GHRP-6 is that GHRP-2 causes far less of an appetite increase than GHRP-6, despite both peptides having a stimulatory effect on ghrelin. As a result, GHRP-2 is better suited for improving lean body composition or when body weight must be kept below certain levels. Conversely, individuals desiring significant weight gain or size increase may do well to consider GHRP-6.

Combination GHRH Peptides

GHRP-2’s two-fold action mechanism, specifically its inhibition of somatostatin, typically allows it to stimulate a greater increase in GH levels than a GHRH peptide such as Sermorelin alone (which only increases pituitary output). Still, even higher natural growth hormone levels can be attained with the combination of GHRP-2 with Sermorelin or peptides such as Mod-GRF and CJC-1295. These GHRH peptides possess complimentary mechanisms of action, affecting different receptors in the pituitary gland than GHRP-2. As a result, when used in combination, even higher growth hormone levels can be achieved. This can result in more performance enhancing effects such as faster muscle tissue growth and repair, better wound healing and recovery, and more rapid fat metabolism (fat loss), as well as even greater anti-aging effects.

Dosage

Amount per administration: 150 – 300mcg (0.15 to 0.3mg)
Administration frequency: 1 to 3 times daily

GHRP-2 is generally administered 1-3 times daily at dosages ranging from 150mcg to 300mcg per administration. For strength gain or performance enhancement, a common protocol is 300mcg administered 3 times a day. These higher dosages provide a substantial increase in growth hormone output to facilitate muscle growth, fat loss, and recovery from training and injury. For anti-aging purposes, lower dosages are often more appropriate; for example, 150mcg prior to bed once daily. These protocols are intended to provide a significant increase in growth hormone production over time while still maintaining a natural pattern of release. For best results, it is recommended to avoid eating at least 1 hour before and after administering GHRP-2.

Importantly, dosages should always be monitored and adjusted by the prescribing physician based on individual results. It is a good practice to start with a more conservative dose at first, increasing only as needed to attain desired results. This helps to avoid excessive doses that can lead to unwanted side effects.

Side Effects

The side effects of GHRP-2 are typically mild. The most common is a slight appetite increase due to the enhanced action of ghrelin. Feelings of tiredness or lethargy are also possible, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities. To avoid this inconvenience (as well as to maximize its beneficial impact on nighttime production of growth hormone), many protocols call for its administration shortly before bed.

Excess dosages of GHRP-2 may lead to water retention as well as tingling or numbness in the hands and feet. This can be a sign that the dosage is too high and should be reduced. GHRP-2 may have a slight stimulatory effect on adrenocorticotropic hormone (ACTH), cortisol, and prolactin when used at higher dosages. Though not an issue for the vast majority of users, this may cause interactions with certain medications or unwanted effects in individuals with certain health conditions.

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