Hexarelin stimulates a powerful increase in natural growth hormone production, promoting lean muscle growth, rapid fat loss, increased tendon and ligament strength, enhanced flexibility, and better recovery from injuries and training sessions.
Hexarelin Acetate (Examorelin)
Hexarelin is a synthetically made growth hormone secretagogue, a peptide that stimulates the body to increase natural production of growth hormone. Growth hormone, or GH, is made in and released by the pituitary gland. Hexarelin works to enhance this natural GH production in two different ways. First, the peptide amplifies the natural growth hormone releasing signal. This results in a greater secretion of GH from the pituitary gland. Second, it suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone (GHIH). Somatostatin causes the body to reduce its natural GH output. By limiting the action of somatostatin, Hexarelin removes this barrier to higher GH production, resulting in significantly increased natural growth hormone levels.
As the most powerful growth hormone releasing peptide, Hexarelin has been shown to bring about a substantial increase in natural growth hormone production, albeit for a limited time (up to approximately 16 weeks). Although cycling the peptide is required for getting the maximum benefit, this is due to a gradual desensitization to Hexarelin’s effect over time, not due to a shutdown of the body’s own natural GH production. Because Hexarelin stimulates the body to produce GH, there is no shutdown of natural growth hormone secretion as occurs with synthetic hGH administration.
Hexarelin causes GH secretion in a way that more closely resembles natural release patterns, causing growth hormone to be released in a “pulse” type manner, rather than being constantly elevated. This results in fewer side effects compared with synthetic hGH. Still, since Hexarelin stimulates such a large pulse of GH release, it has been hypothesized that this may be responsible for the gradual decline in the body’s response to administration over time. However, studies have shown that with proper cycling protocols, Hexarelin can continue to be fully effective once resumed after sufficient time off from administration (generally 4 to 8 weeks).
Also Known As: Examorelin, Hexarelin Acetate
Amino Acid Sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular Formula: C47H58N12O6
Molar Mass: 887.04022
The benefits of Hexarelin include lean muscle growth, rapid fat loss, increased tendon and ligament strength, and enhanced flexibility and joint health. It also promotes better recovery from injuries and training sessions, resistance to musculoskeletal injury, deeper, more restful sleep, and improved overall health and wellness. Athletic performance, physical capacity, and recovery all have the ability to improve dramatically with the use of this powerful growth hormone stimulating peptide.
By increasing natural growth hormone levels, Hexarelin also enhances production of Insulin-like Growth Factor 1 (IGF-1) in the body. This further drives the growth of lean muscle tissue, improving strength and body composition. Likewise, Hexarelin promotes significant gains in athletic performance, preventing musculoskeletal injury while reducing recovery time between training sessions. In addition, its method of action prevents many of the negative side effects of synthetic hGH administration, including the shutdown of natural growth hormone production.
Hexarelin is regarded as the most potent growth hormone releasing peptide (GHRP), promoting the largest rise in natural growth hormone of all the GH stimulating peptides. However, the effects of Hexarelin have been observed to plateau in clinical studies with use exceeding approximately 16 weeks. Cycling this peptide is therefore critical in order to continue getting long term benefits. As a result of its powerful short term effects combined with its cycling requirements, Hexarelin is best suited for athletic performance enhancement rather than anti-aging purposes.
Hexarelin Vs. Sermorelin and Ipamorelin
Synergistic Combination With GHRH Peptides
Hexarelin’s potent growth hormone stimulating effect enables it to bring about a greater short term increase in GH levels than other growth hormone releasing peptides or GHRH peptides alone. Still, even higher natural growth hormone levels can be attained with the combination of Hexarelin with peptides like Sermorelin, Mod-GRF, or CJC-1295. These GHRH peptides possess complimentary mechanisms of action, affecting different receptors in the pituitary gland than Hexarelin.
As a result, when used in combination, one can achieve an even more substantial increase in growth hormone levels for the duration of a cycle. This can result in greater performance enhancing effects such as faster muscle tissue growth and repair, significantly improved wound healing and recovery, and considerable gains in strength and endurance.
Amount per administration: 100mcg
Administration frequency: 2 to 3 times daily
Hexarelin is generally administered 2-3 times daily at dosages of 100mcg per administration. As Hexarelin is best suited for athletic performance enhancement rather than anti-aging purposes, it is commonly administered at least 2 times per day to increase growth hormone as much as possible in the limited duration of a cycle (up to 16 weeks). These dosages provide a substantial increase in growth hormone output to facilitate muscle growth, strength gain, fat loss, and recovery from training and injury. For best results, it is recommended to avoid eating 1 hour before and after administering Hexarelin.
Common side effects of Hexarelin can include feelings of tiredness or lethargy, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities. Although Hexarelin is a growth hormone releasing peptide, it does not stimulate an increase in appetite through increased ghrelin activity.
Excess dosages may lead to water retention as well as tingling or numbness in the hands and feet. This can be a sign that the dosage is too high and should be reduced. Hexarelin may have a stimulatory effect on adrenocorticotropic hormone (ACTH), cortisol, and prolactin. Though not an issue for the vast majority of users, this may cause interactions with certain medications or unwanted effects in individuals with certain health conditions.