Ipamorelin increases natural growth hormone production, promoting muscle growth, fat loss, anti-aging effects, and improved overall health and wellness.
What is Ipamorelin?
Ipamorelin is a synthetically made growth hormone secretagogue, a peptide that stimulates the body to increase natural production of growth hormone. Growth hormone, or GH, is made in and released by the pituitary gland. Ipamorelin works to enhance this natural GH production in two different ways. First, the peptide amplifies the natural growth hormone releasing signal. This results in a greater secretion of GH. Second, it suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone (GHIH). Somatostatin causes the body to reduce its natural GH output. By limiting the action of somatostatin, Ipamorelin removes this barrier to higher GH production, resulting in increased natural growth hormone levels. Unlike GHRP-6 and GHRP-2, Ipamorelin has no effect on ghrelin levels in the body. This prevents it from increasing appetite, a desirable effect for those looking to lose body fat or maintain a consistent weight over time with long-term administration for anti-aging purposes.
Because Ipamorelin stimulates the body to produce GH, there is no shutdown of natural growth hormone production like that which occurs with synthetic hGH administration. Ipamorelin causes GH secretion in a way that more closely resembles natural release patterns, causing growth hormone to be released in a “pulse” type manner, rather than being constantly elevated. This results in fewer side effects compared with synthetic hGH. Ipamorelin creates a smoother, less intense pulse of GH release with a longer duration than most other GHRPs as well, causing GH elevation for up to 3 hours after administration.
Also Known As: NNC 26-0161
Amino Acid Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molecular Formula: C38H49N9O5
Molar Mass: 711.85296
Ipamorelin has powerful anti-aging benefits. Athletic performance, physical capacity, and recovery all may improve dramatically with the use of this peptide, particularly in those with an aging-related decline in growth hormone levels. Specific benefits include increased muscle mass, decreased body fat, and enhanced flexibility and joint health. It also promotes better recovery from injuries and training sessions, deeper, more restful sleep, and improved overall health and wellness.
Ipamorelin also enhances production of Insulin-like Growth Factor 1 (IGF-1) in the body. This further drives improvements in recovery, strength, and lean body mass by accelerating muscle growth and enhancing tissue repair. In addition, Ipamorelin’s method of action prevents many of the negative side effects of synthetic hGH administration, including the shutdown of natural growth hormone production.
Ipamorelin is regarded as one of the mildest growth hormone releasing peptides in terms of negative side effects. Even with long term use, concerns of adverse effects are rarely reported. Additionally, it has a negligible effect on cortisol, prolactin, and appetite, unlike other GHRPs. As a result of its targeted effects on natural growth hormone production and its well-tolerated profile, Ipamorelin is one of the most widely sought-after anti-aging peptides.
Difference Between Ipamorelin, Sermorelin, and Hexarelin
Synergistic Combination With GHRH Peptides
Higher natural growth hormone levels can be attained with the combination of Ipamorelin with peptides like Mod-GRF or CJC-1295. These GHRH peptides possess complimentary mechanisms of action, affecting different receptors in the pituitary gland than Ipamorelin. As a result, when used in combination, higher growth hormone levels can be achieved. This can result in more performance enhancing effects such as faster muscle tissue growth and repair, better wound healing and recovery, and more rapid fat metabolism (fat loss), as well as even greater anti-aging effects.
Amount per administration: 200 to 300mcg (0.2 to 0.3mg)
Administration frequency: 1 to 3 times daily
Ipamorelin is generally administered 1-3 times daily at dosages ranging from 200mcg to 300mcg per administration. For strength gain or performance enhancement, a common protocol is 300mcg administered 3 times a day. These higher dosages provide a substantial increase in growth hormone output to facilitate muscle growth, fat loss, and recovery from training and injury. For anti-aging purposes, lower daily dosages are often more appropriate; for example, 200mcg prior to bed once daily. These protocols are intended to provide a significant increase in growth hormone production over time while still maintaining a natural pattern of release. For best results, it is recommended to avoid eating at least 1 hour before and after administering Ipamorelin.
Importantly, dosages should always be monitored and adjusted by the prescribing physician based on individual results. It is a good practice to start with a more conservative dose at first, increasing only as needed to attain desired results. This helps to avoid excessive doses that can lead to unwanted side effects.
Ipamorelin is widely regarded as the most well-tolerated growth hormone secretagogue. Any side effects that may occur are typically mild and dose-dependent, with negative effects rarely occurring at moderate dosage levels. Generally, mild flushing or headache may occur upon initial administration, though this commonly goes away after repeated injections. Temporary nausea and upset stomach may additionally occur following administration. Feelings of tiredness or lethargy are also possible, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities. To avoid this inconvenience (as well as to maximize its beneficial impact on nighttime production of growth hormone), many protocols call for its administration shortly before bed.
Ipamorelin does not elevate adrenocorticotropic hormone (ACTH), cortisol, and prolactin when used as recommended. When used at extremely high dosages, however, it can have a stimulatory effect on these hormones. Though not an issue for the vast majority of users, this may cause interactions with certain medications or unwanted effects in individuals with certain health conditions. Excessive dosages of Ipamorelin may also lead to water retention as well as tingling or numbness in the hands and feet. This can be another sign that the dosage is too high and should be reduced.