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Modified GRF 1-29


Structure:  Tyr-D-Ala-Asp-Ala-lle-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-lle-Leu-Ser-Arg


Modified GRF 1-29 is a synthetically made form of growth hormone releasing hormone (GHRH), the chemical in the body responsible for stimulating natural growth hormone production. Sometimes referred to as CJC-1295 without DAC, it is categorized as a growth hormone secretagogue, a compound which stimulates increased secretion of growth hormone from the pituitary gland.


Modified GRF 1-29 is used to stimulate natural growth hormone production. This promotes greater muscle and lean body mass, decreased body fat, and enhanced recovery from injuries and training sessions. This can also improve deeper, more restful sleep, enhance flexibility and joint health, and improve overall health and wellness. Growth hormone is an essential component in numerous physiological processes, with substantial influence in the facilitation of strength, energy, flexibility, vitality, and overall well-being. Aging-related decline in growth hormone production is responsible for many of the debilitating effects commonly associated with maturing.

Enhanced growth hormone levels also stimulate greater production of Insulin-like Growth Factor -1 (IGF-1) in the body, driving improvements in body composition with accelerated growth of muscle tissue. As Modified GRF 1-29 stimulates the body’s natural growth hormone output, none of the negative side effects often associated with synthetic hGH administration typically occur. This avoids the shutdown of natural growth hormone production as well as adverse effects like acromegaly and carpal tunnel syndrome, conditions that typically arise from extreme, unnatural amounts of growth hormone in the body.

Mechanism of Action

Similar to the body’s natural GHRH, Modified GRF 1-29 functions by binding to the growth hormone releasing hormone receptor (or GHRHr) in the anterior part of the pituitary gland. There, it works to amplify the pulsatile release of growth hormone, consequently provoking increases in production of IGF-1. Modified GRF 1-29 works most effectively when administered at the same time as a release of growth hormone in the body. This can be accomplished by timing administration with the body’s natural growth hormone release or by administering it along with a GHRP to further amplify both peptides’ effects.

As it exerts its effects in a similar manner to GHRH, Modified GRF 1-29’s positive effect on growth hormone output is modulated by a negative feedback mechanism initiated by somatostatin, the endogenous hormone also known as growth hormone inhibiting hormone (GHIH). This has several positive effects, the first of which is the prevention of extreme, unhealthy growth hormone levels in the body. Second, it allows for more natural patterns of fluctuation in growth hormone concentrations. These both help to avoid negative side effects that often accompany the administration of artificial hGH.


Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area.

Before administering Modified GRF 1-29, always be sure to use a clean and sterile syringe.

  1. Hold the Modified GRF 1-29 vial upright and insert the syringe in the center of the cap.
  2. Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
  3. Before administering the syringe, use alcohol to cleanse the area of skin.
  4. Pinch the skin around the area to be injected, leave about 2 cm on each side.
  5. Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
  6. Depress the plunger fully, until the syringe is empty, and carefully draw out.


Dosage Amount:100mcg (0.1mg)

Dosage Frequency:1 - 3 times daily

For anti-aging purposes, 100mcg of Modified GRF 1-29 can be administered once daily before bed. This protocol can provide a significant increase in growth hormone production over time while still mirroring natural patterns of growth hormone release. For strength gain and performance enhancement, 100mcg can be administered 3 times a day in combination with a GHRP. A higher dosage of Modified GRF 1-29 in conjunction with the use of a GHRP can provide a substantial increase in growth hormone output, facilitating muscle growth, fat loss, and recovery from training and injury.

Side Effects

Modified GRF 1-29 has side effects that are typically mild and dose-dependent, with negative effects rarely occurring at moderate dosage levels. Upon initial administration, some symptoms may occur, such as: mild skin flushing, nausea, stomach upset, dizziness, and/or headache. These reactions tend to dissipate after repeated injections. Feelings of tiredness or lethargy are possible as well, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities.

Excessive dosages of Modified GRF 1-29 may also lead to tingling or numbness in the hands and feet. Water retention can be another sign that the dosage is too high and should be reduced. As always, it is recommended to discontinue use and call a physician immediately if any negative side effects are suspected.


  • Increase in muscle growth and lean body mass
  • Acceleration of wound healing from injury or training
  • Enhancement of fat burning and weight loss
  • Improvement in bone growth
  • Increase metabolism
  • Improvement of the immune system and blood sugar regulation
  • Enhancement of flexibility and joint health
  • Improvement of quality of sleep and rest
  • Increase in energy, vitality and overall wellness